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Innovative cancer data resource expands, gains a new name
Academics and policymakers are using the Cancer Information & Population Health Resource, or CIPHR, to knit together data from multiple public and private sources to examine a wide range of complex issues tied to improving cancer outcomes in North Carolina.
Located in News
Study sheds light on why some breast cancers have limited response to immunotherapy
Jonathan Serody, MD, Benjamin Vincent, MD, and a team of UNC Lineberger investigators published findings in the Journal of Clinical Investigation that may explain why drugs designed to unleash the immune system against cancer were ineffective in treating a type of triple negative breast cancer. They determined “claudin-low” tumors were releasing a chemical signal to attract regulatory T-cells, which prevented the immune system from rejecting the cancer.
Located in News
Kim senior authors study in JCO Precision Oncology
William Y. Kim, MD, has published a study in JCO Precision Oncology that uncovered possible treatment approaches for urachal adenocarcinoma, a rare bladder cancer.
Located in Newsletters / / Honors and Awards / 2017
Using ‘sticky’ nanoparticles, researchers develop new strategy to boost body’s cancer defenses
In the journal Nature Nanotechnology, UNC Lineberger researchers led by Andrew Wang, MD, report on strides made in the development of a strategy to improve the immune system's detection of cancer proteins by using “sticky” nanoparticles.
Located in News
New models of kidney cancer may drive immunotherapy research
UNC Lineberger member William Y. Kim, MD, and his colleagues report in the journal Nature Communications they have created laboratory models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers.
Located in News
UNC-Chapel Hill spinout company generates more than $108M in stock offering
Founded with support from KickStart Venture Services, a UNC-Chapel Hill program that works to turn University research into new companies, G1 Therapeutics is developing novel therapeutics based on discoveries at UNC Lineberger Comprehensive Cancer Center.
Located in News
In ovarian cancer, researchers uncover new drivers of cell division
UNC Lineberger's Michael J. Emanuele, PhD, and colleagues have identified a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide, a finding they published in the journal Molecular and Cellular Biology. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.
Located in News
Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy
In a pair of preclinical studies published in the journal Neuro-Oncology, UNC Lineberger's C. Ryan Miller, MD, PhD, and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.
Located in News
Study confirms link between alcohol consumption, breast cancer risk in black women
In findings published in the journal Cancer, Epidemiology, Biomarkers & Prevention, UNC Lineberger Comprehensive Cancer Center researchers confirmed the link between alcohol consumption and breast cancer risk in a study in black women. The association has been seen in other studies drawn from majority white populations.
Located in News
Images of health risks make indoor tanning messages more effective
UNC Lineberger's Seth Noar, PhD, and colleagues report in a new study that anti-tanning bed messages with images showing longer-term health effects, such as skin cancer or wrinkles, produced greater negative emotional reactions and higher ratings of effectiveness in a survey of female college students than text-only messages.
Located in News