Recent News

U.S. cancer death rate declines, but work is needed to address local disparities

U.S. cancer death rate declines, but work is needed to address local disparities

UNC Lineberger researchers Ethan Basch, MD, MSc, and Stephanie Wheeler, PhD, MPH, called for tailored, local-level cancer prevention, screening and treatment efforts to address regional disparities in cancer mortality rates in an editorial published in the Journal of the American Medical Association.

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Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

In the journal Cancer Discovery, UNC Lineberger's Gary Johnson, PhD, and colleagues published findings on how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved kinase inhibitor. They also demonstrated in a laboratory model a potential treatment approach that could prevent the onset of resistance.

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Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse

A team of researchers, including UNC Lineberger's Norman E. Sharpless, MD, has shown that chemotherapy triggers a pro-inflammatory stress response termed cellular senescence, promoting the adverse effects of chemotherapy as well as cancer relapse and metastasis. Eliminating the senescent cells in mice prevented the side effects and relapse.

Study: Pro-inflammatory stress response promotes chemotherapy side effects and cancer relapse - Read More…

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer

Backed by a three-year, more than $1.8 million grant from the National Cancer Institute, UNC Lineberger researchers Ryan Miller, MD, PhD, and Gary Johnson, PhD, plan to develop better cancer models to identify patterns of drug resistance in glioblastoma.

Researchers awarded NCI grant to seek new treatments for deadliest adult brain cancer - Read More…