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Greg Wang

Greg Wang

  • Ph.D.
  • Cancer Cell Biology

  • School of Medicine
  • UNC-Chapel Hill
  • greg_wang@med.unc.edu
  • 966-5952
  • LCCC room 31-327

Area of Interest

With an emphasis on chromatin biology and cancer epigenetics, our group focuses on mechanistic understandings of how chemical modifications of chromatin define distinct patterns of human genome, control gene expression, and regulate cell proliferation versus differentiation during development, and how their deregulations lead to oncogenesis. Multiple on-going projects employ modern biological technologies to: 1) biochemically isolate and characterize novel factors that bind to histone methylation on chromatin, 2) examine the role of epigenetic factors (chromatin-modifying enzymes and chromatin-associated factors) during development and tumorigenesis using mouse knockout models, 3) analyze epigenomic and transcriptome alternation in cancer versus normal cells utilizing next-generation sequencing technologies, 4) identify novel oncogenic or tumor suppressor genes associated with leukemia and lymphoma using shRNA library-based screening. We?re also working together with UNC Center of Drug Discovery to develop small-molecule inhibitors for chromatin-associated factors as novel targeted cancer therapies.

Awards and Honors

2007 C. H. Li Memorial Scholar Fund Scholar Award, the Rockefeller University
2008-2010 Leukemia & Lymphoma Society Fellow Award
2008 Irvington Institute - Cancer Research Institute postdoctoral fellowship (declined)
2008 named as the John C. Newman researcher of Leukemia & Lymphoma Society
2010 the Howard Temin ?Pathway to Independence? Award in Cancer Research, NIH/NCI
2011 Martin D. Abeloff, MD V Scholar Award, the V Foundation for Cancer Research