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Emmanuel E. Zervos

Emmanuel E. Zervos

  • M.D.
  • Immunology

  • Surgical Oncology
  • ECU
  • ZERVOSE@ecu.edu
  • 813-844-4006
  • Brody School of Medicine Greenville, NC, 27834

Area of Interest

My research interests are focused on immunotherapeutic strategies to treat surgically resectable and unresectable pancreatic cancer. I have successfully transferred a funded NCI protocol from the Moffitt Cancer Center in Tampa utilizing a novel method of combining apoptosis induction with a dendritic cell based vaccine. This protocol has accrued half of the requisite 35 patients and is now open in Greenville. Biologic correlates examining the immune response, both local (immune cell infiltrate) and systemic (T cell recognition of candidate universally expressed pancreatic cancer antigens) , to this strategy will form the basis of a subsequent R-01 submission. This follow up study will explore various strategies designed to improve immune cell recognition of pancreatic tumors by identifying candidate antigens to pulse DC. For the current trial, we are continuing to utilize the cell therapies facility at Moffitt for DC preparation; my intention is to collaborate with the immunotherapy / cell therapy core at Lineberger for subsequent studies.

Awards and Honors

1995 1st Place, Resident Research Competition, Florida Surgical Society
1995 SSAT / Ross Resident Research Award
1996 Florida Committee on Trauma, Resident Paper Competition Award, 1st Place
1996 1st Place, Resident Research Competition, Florida Surgical Society
1997 1st Place, Physicians in Training Paper Competition Southern Medical Association
1997 Watson Clinic Award - Best Research Presentation USF Research Day
1998 Frederick A. Coller Surgical Society, Coller Society Clinical Tour
1998 Elected to Alpha Omega Alpha Medical Honor Society
1999 Society of Abdominal Surgeons Resident Research Award
2000 Successful completion of American Board of Surgery Qualifying Exam
2001 Scholarship Recipient American Association for Cancer Research Molecular
Biology in Clinical Oncology, Aspen, CO July 2000
2002 Scholarship Recipient American Association of Clinical Oncology (ASCO) Methods in Clinical Cancer Research , Vail, CO
2001 Columbus Surgical Society: 1st Place Resident Paper Competition
2001 American Society of Breast Surgeons: Best Poster Presentation, La Jolla, CA
May 2001
2001 Ohio State University: 1st Place Resident Paper Competition Mentor
2003 Association of VA Surgeons Best Scientific Presentation
2004 USF Research Day Best Scientific Poster