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The Oncology Protocol Review Committee (PRC) is a multidisciplinary standing committee of the UNC Lineberger Comprehensive Cancer Center.

Its charge is the peer review of investigator initiated, industry sponsored and cooperative group research protocols involving cancer patients, or those conducted by UNC investigators with a focus on cancer, prior to submission of the protocol to the UNC Institutional Review Board (IRB).

The PRC’s primary function is to ensure the scientific merit of the proposed research and ensure patient safety parameters of proposed studies and protocol amendments. The PRC also monitors study accrual (via annual renewal review) and recommends closure of under-performing trials.